The clinical efficacy of leukocyte-poor platelet-rich plasma in arthroscopic rotator cuff repair: a meta-analysis of randomized controlled trials

BackgroundThe efficacy of platelet-rich plasma (PRP) in the arthroscopic treatment rotator cuff injury has been reported literature. However, conclusions have inconsistent and more often related to differences types PRP used. Therefore, minimize these differences, we performed a meta-analysis only studies investigating leukocyte-poor evaluate whether promotes improves effects repair.MethodsA comprehensive search PubMed, Embase, Cochrane Library databases was conducted repair. The available data were extracted, methodologic quality included evaluated by risk-of-bias assessment tool.ResultsIn total, 10 randomized controlled trials involving 742 patients included. results showed that with better than control relieving postoperative pain short-term (mean difference [MD], –0.57; 95% confidence interval [CI], –0.79 –0.35; P < .0001) medium- long-term (MD, –0.18; CI, –0.34 –0.03; = .02) follow-up groups. changes MD visual analog scale score below minimal clinically important difference. Regarding Constant shoulder 3.35; 1.68-5.02; University California, Los Angeles 1.73; 0.94-2.52; scores, statistically significant found favor over treatment. both scores Moreover, during follow-up, retear rate group lower regardless tear size (small medium [<3 cm] [risk ratio (RR), 0.64; 0.43-0.97; .03] vs. large [>3 [RR, 0.51; 0.34-0.77; .001]) surgical repair method (single-row 0.61; 0.43-0.87; .007] double-row suture bridge 0.57; 0.38-0.84; .005]).ConclusionAccording our study, can significantly reduce long term used for use failed show meaningful terms patient-reported outcomes. A tool. In .005]). According